Drug identified for cancer!!

Drug identified for cancer!!

A molecule that can help treat breast cancer Scientists, including an Indian-American researcher, has been identified by, giving hope to patients who have become resistant to traditional therapies.In a new waythe first-in-class molecule shuts down oestrogen-sensitive breast cancer.By a unique mechanism first-in-class drugs work - in this case a molecule that targets a protein on the oestrogen receptor of tumour cells.For patients whose breast cancer has become resistant to traditional therapies this potential drug offers hope."This is a fundamentally different, new class of agents for oestrogen-receptor-positive breast cancer.”Its unique mechanism of action overcomes the limitations of current therapies.To determine if they require oestrogen to grow and about 80 per cent are found to be oestrogen-sensitive, all breast cancers are tested.With the help of hormone therapythese cancers can often be effectively treated, such as tamoxifen, but as many as a third of these cancers eventually become resistant. For these patients the new compound is a potential highly effective, next-line treatment.Hormonal drugs, such as tamoxifen, work by attaching to a molecule called the oestrogen receptor in cancer cells, preventing oestrogen from binding to the receptor, a necessary step for cancer cells to multiply.However, the oestrogen receptor can mutate and change its shape over time so that the treatment drug no longer fits neatly with the receptor. When this happens, the cancer cells start multiplying again.For them they have the interest in developing drugs that block the ability of the oestrogen receptor the prime target in most breast cancers is interacting with the co-regulator proteins that cause a tumour's growth.Since from decades, blocking such "protein-protein interactions" has been a dream of cancer researchers.The drug works by blocking other molecules proteins called co-factors that also must attach to the oestrogen receptor for cancer cells to multiply.

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