Model study by researchers to cure cancer!

Model study by researchers to cure cancer!

A mouse model study has been created by a group of scientists has created which may be able to cure Leukemia. The model helps to study blood disorders and bone marrow that could help find a cure for blood and bone marrow cancer. A research team led by Professor Maneesha S Inamdar at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bengaluru has created the model. The research team has discovered a stem cell protein called 'asrij' (meaning blood in Sanskrit), has found it plays a key role in preventing myeloproliferative disease. The article named as "Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence" is a contribution of the research of the team comprising of Saloni Sinha, Tirath Raj Dwivedi, Roja Yengkhom, Venkata Anudeep Bheemsetty, Takaya Abe, Hiroshi Kiyonari, K VijayRaghavan and Inamdar. 90 per cent of cancer cases are caused due to the mutation of a protein which regulates cell production-p53. Only 11 per cent of hematologic malignancies (cancer in the cells of blood-forming tissue) have mutant p53. Mechanisms that cause wild type p53 dysfunction and promote leukemia are inadequately deciphered. "Despite no significant mutation of p53, we found levels of asrij were low, causing uncontrolled production of new cells. According to them, the protein asrij protects p53 and helps in preventing cancer. Without asrij, p53 is destroyed and the blood stem cells multiply making it cancerous. This new research explains how some cancer cells develop without a mutation in p53. It is a well-known fact among the scientists that mutations in p53 lead to cancer but they were unable to figure out how and this study will help them to understand it. The research was done in collaboration with RIKEN CDB, Kobe, Japan and the National Centre for Biological Sciences, Bengaluru.

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